ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Association of serum pentraxin 3 levels with co-morbidities in acute ischemic stroke patients
Abstract
Aims: Pentraxin 3 (PTX3), an indicator of the inflammatory process, is an acute-phase protein (AP) with biphasic effect. In the present study, the relationship between PTX3 levels and stroke risk factors in stroke patients were analyzed.
Methods: Acute stroke patients (n=56) were diagnosed using imaging techniques and clinical examination along with and their laboratory results. The control group consisted of thirty healthy individuals. Blood samples of the patient group were obtained within the first 24 hours of stroke onset. Serum pentraxin levels of both groups were analyzed and their relationship with stroke risk factors evaluated.
Results: A total of 86 people, 56 stroke patients and 30 healthy controls were included in the present study. Out of the participants, in both groups, 50% were female (p=1.000). No significant difference was determined between the groups in terms of age (p=0.226). The pentraxin value in the patient group was significantly lower than that in the control group (p=0.003). No significant difference between gender and presence of comorbidities in terms of PTX3 value (p>0.05) were present. Likewise, no significant correlation could be established between PTX3 value and National Institutes of Health Stroke Scale (NIHSS) and age in the patient group.
Conclusion: Serum PTX3 can be used as a biomarker in acute stroke patients. However, it cannot be used as a predicator in determining prognosis during the acute period.

Keywords : Stroke, pentraxin 3, NIHSS, comorbidity

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Article available in :
Volume 7, Issue 3, 2025
Page : 358-362
https://doi.org/10.38053/acmj.1618793
Article Information
Received : 13 Oca 2025
Accepted : 17 May 2025
Published : 30 May 2025
Corresponding Author :

Filiz Demirdöğen: Department of Neurology, Faculty of Medicine, Erzurum Atatürk University, Erzurum, Turkiye

[email protected]
Citation : Demirdöğen F. Association of serum pentraxin 3 levels with co-morbidities in acute ischemic stroke patients. Anatolian Curr Med J. 2025;7(3):358-362.

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