ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Inflammatory biomarkers in Hashimoto’s thyroiditis: a comparative cross-sectional study
Abstract
Aims: Hashimoto's thyroiditis (HT) is an autoimmune disorder impacting majorly females. HT is asymptomatic long-term and known to be affected by metabolic factors, genetics, and inflammation. The study aimed to compare inflammatory and metabolic markers in HT and assess their value in the diagnosis.
Methods: An HT group (n=103) and a control group with euthyroidism (n=103) were included in the study. The demographics, anthropometric measurements, and circulation-based inflammatory and metabolic markers, triglyceride-glucose index, FIB-4 score, non-alcoholic fatty liver disease score, APRI, ATH score, systemic immune-inflammation index, systemic inflammation response index, prognostic nutritional index, monocyte-to-HDL cholesterol ratio, atherogenic index of plasma, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, PV, PDW, and RDW were recorded.
Results: Consistent with the literature, we found a 10-fold difference in the HT prevalence in females (90.3%) compared with males (9.7%). Anthropometric measurements revealed that increased hip circumference increases the risk of HT (118.0 cm [107.0–132.0]) compared to control (110.0 cm [103.0–119.0]). We failed to find any difference in metabolic or inflammatory indices in the HT vs. control group.
Conclusion: This study reinforces the well-documented association between HT and female predominance and metabolic factors such as obesity and diabetes. However, inflammatory markers did not show a significant association with HT, urging the need for larger cohorts.

Keywords : Hashimoto thyroiditis, inflammatory markers, hip circumference, metabolic markers

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Article available in :
Volume 7, Issue 3, 2025
Page : 291-296
https://doi.org/10.38053/acmj.1667024
Article Information
Received : 28 Mar 2025
Accepted : 13 Nis 2025
Published : 30 May 2025
Corresponding Author :

Muzaffer Serdar Deniz: Department of Endocrinology, Karabük University Training and Research Hospital, Karabük, Turkiye

[email protected]
Citation : Deniz MS, Coşkun A. Inflammatory biomarkers in Hashimoto’s thyroiditis: a comparative cross-sectional study. Anatolian Curr Med J. 2025;7(3):291-296.

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