ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
The diagnostic value of eosinophil-to-lymphocyte ratio in predicting contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction
Abstract
Aims: Inflammation is considered a major contributor to the development of contrast-induced nephropathy (CIN). The purpose of this study was to assess the effectiveness of eosinophil-to-lymphocyte ratio (ELR) as a predictor of CIN among patients who experienced percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI).
Methods: The study involved 440 patients diagnosed with STEMI who underwent primary PCI. The participants were categorized into two classes based on whether they had CIN or not. ELR was calculated by dividing the eosinophil count by the lymphocyte count.
Results: The group with CIN (+) showed significantly higher ELR levels (0.134±0.063 vs. 0.069±0.037, p<0.001). According to the ROC curve assessment, the best threshold level of ELR to predict CIN development was identified as 0.093, with 75.9% sensitivity and 79.1% specificity (AUC: 0.836; 95% CI: 0.783–0.889; p<0.001). Logistic regression analysis revealed that estimated glomerular filtration rate (eGFR), C-reactive protein, left ventricular ejection fraction, and ELR were independent predictors of CIN.
Conclusion: ELR could be an effective and reliable marker to predict CIN development in individuals with STEMI who undergo primary PCI. Early prediction of CIN risk is critical to provide intensive preventive measures for high-risk patients.

Keywords : Eosinophil-to-lymphocyte ratio, contrast-induced nephropathy, percutaneous coronary intervention, ST-segment elevation myocardial infarction

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Article available in :
Volume 7, Issue 2, 2025
Page : 120-125
https://doi.org/10.38053/acmj.1605520
Article Information
Received : 26 Ara 2024
Accepted : 23 Oca 2025
Published : 21 Mar 2025
Corresponding Author :

Orhan Karayiğit: Department of Cardiology, Yozgat City Hospital, Yozgat, Turkiye

[email protected]
Citation : Karayiğit O, Gök M, Balun A, Kurtul A. The diagnostic value of eosinophil-to-lymphocyte ratio in predicting contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction. Anatolian Curr Med J. 2025;7(2):120-125.

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