ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
The effect of inflammatory scores on the prognosis of malignant mesothelioma
Abstract
Aims: Malignant mesothelioma (MM) is a rare cancer with a poor prognosis that is frequently detected late in the disease's progression. The purpose of our sudy was to contribute to the literature by investigating how inflammation indices such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), prognostic nutritional index (PNI), systemic inflammation response index (SIRI), and HALP scores affect disease progression and prognosis in patients with MM.
Methods: This study retrospectively examined 85 patients pathologically diagnosed with malignant pleural and peritoneal mesothelioma. NLR, PLR, LMR, PNI, SIRI, and HALP scores of the patients were calculated.
Results: The area under the curve (AUC) values obtained by ROC analysis are NLR (0.65), PLR (0.67), LMR (0.66), PNI (0.64), SIRI (0.66), and HALP (0.77). The cut-off values were as follows: NLR (3.2), PLR (168.5), PNI (35.2), LMR (2.5), SIRI (2.2) and HALP (22.8). In multivariate analysis, being inoperable was found to be associated with lower survival, while receiving chemotherapy and high PNI value were found to be associated with higher survival (p<0.05).
Conclusion: In our study, patients with high PNI had longer median survival time. This score can serve as a simple and useful scoring system for predicting the prognosis of malignant pleural mesothelioma in clinical practice.

Keywords : Inflammation indices, malignant mesothelioma, prognostic nutritional index

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Article available in :
Volume 7, Issue 1, 2025
Page : 67-71
https://doi.org/10.38053/acmj.1598805
Article Information
Received : 09 Ara 2024
Accepted : 26 Ara 2024
Published : 10 Oca 2025
Corresponding Author :

Esma Sevil Akkurt: Department of Chest Diseases, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkiye

[email protected]
Citation : Akkurt ES, Düvenci Birben Ö, Yenibertiz D, Dağlı D. The effect of inflammatory scores on the prognosis of malignant mesothelioma. Anatolian Curr Med J. 2025;7(1):67-71.

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