ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Termination of pregnancy for fetal anomaly: evaluation of single centre results
Abstract
Aims: To assess the indications of termination of pregnancies (TOP) for fetal anomaly beyond 22 weeks of gestation.
Methods: It is a retrospective study conducted at Eskişehir City Hospital between January 2021 and December 2023. Our hospital which It serves as a tertiary referral center in the city. During the research period, 4143 births took place, and 495 women were treated in our high-risk unit. During the study period, 34 women underwent elective TOP at at least 22 weeks’ gestation. Routine 18–20-week anomaly screening was recommended for all pregnant women.
Results: The sonographic findings revealed the presence of 15 cases of central nervous system malformation, 4 cases of micromelia and thorax hypoplasia, 1 case of diafragma hernia, 3 case of early IUGG, 2 cases of cardiac anomaly, 2 cases of neural tube defect, 3 cases of isolated thorax hypoplasia, 1 case of scoliosis, 1 case of renal agenesis, 1 case of thick nuchal fold, 1 case of partial corpus collosum agenesis. Among 34 cases, there were 1 case of mosaic trisomy 21, case of trisomy 21, 1 case of trisomy 1, 3 cases of trisomy 13, 2 cases of trisomy 18. Array analysis revealed a case of 14 p deletion, 1 case of 16 p 11.2 deletion, 1 case of 1p36 deletion. In all study population 5 cases underwent cesarean delivery. Majority of the terminations were achieved by misoprostol or cervical balloon application.
Conclusion: In conclusion, although late termination of pregnancy by fetocide procedure seems to be safe, earlier detection of fetal structural and chromosomal anomalies is mandatory.

Keywords : Fetosid, termination of pregnancy, fetal anomaly

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1. Stoll C, Tenconi R, Clementi M. Detection of congenital anomalies by fetal ultrasonographic examination across Europe. <em>Community Genet.</em> 2001;4(4):225-232.
2. Aslan H, Yildirim G, Ongut C, Ceylan Y. Termination of pregnancy for fetal anomaly. <em>Int J Gynaecol Obstet</em>. 2007;99(3):221-224. doi: 10.1016/j.ijgo.2007.05.047
3. Vaknin Z, Ben-Ami I, Reish O, Herman A, Maymon R. Fetal abnormalities leading to termination of singleton pregnancy: the 7-year experience of a single medical center. <em>Prenat Diagn. </em>2006;26(10):938-943.
4. Dommergues M, Benachi A, Benifla JL, des Noettes R, Dumez Y. The reasons for termination of pregnancy in the third trimester. <em>Br J Obstet Gynaecol</em>. 1999;106(4):297-303.
5. Guillem P, Fabre B, Cans C, Robert-Gnansia E, Jouk PS. Trends in elective termination of pregnancy between 1989 and 2000 in a French county (the Isere). <em>Prenat Diagn.</em> 2003;23(11):877-883.
6. Dickinson JE. Late pregnancy termination within a legislated medical environment. <em>Aust N Z J Obstet Gynaecol</em>. 2004;44(4):337-341.
7. Amini H, Antonsson P, Papadogiannakis N, et al. Comparison of ultrasound and autopsy findings in pregnancies terminated due to fetal anomalies. <em>Acta Obstet Gynecol Scand.</em> 2006;85(10):1208-1216.
8. Ramalho C, Matias A, Brandao O, Montenegro N. Critical evaluation of elective termination of pregnancy in a tertiary fetal medicine center during 43 months: correlation of prenatal diagnosis findings and postmortem examination. <em>Prenat Diagn</em>. 2006;26(11):1084-1088.
9. Senat MV, Fischer C, Ville Y. Funipuncture for fetocide in late termination of pregnancy. <em>Prenat Diagn.</em> 2002;22(5):354-356.
10. Allan LD. Cardiac anatomy screening: what is the best time for screening in pregnancy? <em>Curr Opin Obstet Gynecol</em>. 2003;15(2):143-146.
11. Senat MV, Fischer C, Ville Y. Funipuncture for fetocide in late termination of pregnancy. <em>Prenat Diagn</em>. 2002;22(5):354-6. doi: 10.1002/pd.290
12. Senat MV, Fischer C, Bernard JP, Ville Y. The use of lidocaine for fetocide in late termination of pregnancy<em>. BJOG</em>. 2003;110(3):296-300.
13. Vause S, Sands J, Johnston TA, Russell S, Rimmer S. Could some fetocides be avoided by more prompt referral after diagnosis of fetal abnormality? <em>J Obstet Gynaecol</em>. 2002;22(3):243-245. doi: 10.1080/01443610220130490
14. Spingler T, Sonek J, Hoopmann M, Prodan N, Abele H, Kagan KO. Complication rate after termination of pregnancy for fetal defects. <em>Ultrasound Obstet Gynecol</em>. 2023;62(1):88-93. doi: 10.1002/uog.26157
15. Karim JN, Bradburn E, Roberts N, Papageorghiou AT. ACCEPTS study. First-trimester ultrasound detection of fetal heart anomalies: systematic review and meta-analysis. <em>Ultrasound Obstet Gynecol</em>. 2022;59(1):11-25. doi: 10.1002/uog.23740
16. Sadlecki P, Walentowicz-Sadlecka M. Prenatal diagnosis of fetal defects and its implications on the delivery mode. <em>Open Med (Wars)</em>. 2023;18(1):20230704. doi: 10.1515/med-2023-0704
Article available in :
Volume 6, Issue 6, 2024
Page : 351-354
https://doi.org/10.38053/acmj.1545553
Article Information
Received : 08 Eyl 2024
Accepted : 01 Eki 2024
Published : 28 Eki 2024
Corresponding Author :

Zafer Bütün: Department of Gynecology and Obstetrics, Private Clinic, Eskişehir, Turkiye

[email protected]
Citation : Kayapınar M, Bütün Z, Akça Salık E. Termination of pregnancy for fetal anomaly: evaluation of single centre results. Anatolian Curr Med J. 2024;6(6):351-354.

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