ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Adjuvant denosumab treatment in patients with resectable high-risk giant cell tumor of bone
Abstract
Aims: Giant cell tumor of bone (GCTB) is an uncommon, benign, but aggressive osteolytic skeletal neoplasm of young adults. Although denosumab is frequently used in neoadjuvant treatment and metastatic unresectable disease in these patients, its role in adjuvant therapy is unclear. In this study, we evaluated the efficacy and safety of denosumab as an adjuvant therapy in patients with resectable high-risk GCTB.
Methods: Patients with resectable high-risk GCTB over the age of 16 who received postoperative denosumab between January 2013 and September 2022 were included. Demographic and clinical characteristics of the patients, tumor localization, prior treatments, response to denosumab treatment, and adverse effects of the drug were analyzed retrospectively.
Results: A total of 18 patients (10 women) with a median age of 23 (16-45) years were recruited. The median follow-up time was 7.1 (4.2-8.7) years and the median denosumab treatment duration was 12 (12-90) months. One (6%) patient experienced a partial response, and 17 (94%) patients had stable disease. Grade 1 or 2 hypophosphatemia was the most frequent adverse effect (16.7%, n=3). No patients stopped therapy due to side effects, and no grade 3 or 4 incident were observed.
Conclusion: Postoperative denosumab may also be useful in the adjuvant treatment of patients with high-risk resectable GCTB.

Keywords : Giant cell tumor of bone, denosumab, adjuvant drug therapy

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Article available in :
Volume 6, Issue 3, 2024
Page : 225-228
https://doi.org/10.38053/acmj.1466741
Article Information
Received : 09 Nis 2024
Accepted : 01 May 2024
Published : 28 May 2024
Corresponding Author :

Arif Akyıldız: Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkiye

[email protected]
Citation : Akyıldız A, Ismayilov R, Güven DC, Chalabiyev E, Abdurrahimli N, Aksoy S. Adjuvant denosumab treatment in patients with resectable high-risk giant cell tumor of bone. Anatolian Curr Med J. 2024;6(3):225-228.

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