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Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Etoposide hypersensitivity reactions and outcomes of desensitizations in immediate-type hypersensitivity reactions
Abstract
Aims: This study aims to define characteristics of hypersensitivity reactions with etoposide, and outcomes of desensitizations in immediate-type hypersensitivity rections
Methods: This is a retrospective observational study of patients who had hypersensitivity reactions with etoposide from January 2019 to December 2023.
Results: A total of 39 patients with lung cancer were included in the study. Ten (25.6%) patients had known other drug allergies and three (7.7%) patients had previous chemotherapeutic hypersensitivity two with paclitaxel and one with docetaxel. Most of the initial hypersensitivities were in the first or second cycle (n=29, 74.4%). Ten (25.4%) patients had hypersensitivity reactions at the first application of etoposide. Thirty (76.9%) patients had immediate-type hypersensitivity reactions. There was no significant difference in terms of patient and initial hypersensitivity characteristics between patients who had immediate or non-immediate type hypersensitivity reactions. Of the 30 patients with immediate-type hypersensitivity reactions, initial reaction was mild in 16 (53.3%) and moderate in 14 (46.7%) patients. Most common symptoms were erythema in 29 (96.7%), dyspnea in 13 (43.3%), chest tightness in 8 (26.7%), discomfortness in 7 (23.3%), and hypertension in 6 (20%). Skin tests were negative in five patients who underwent skin testing. A total of 98 desensitization courses were performed in 27 patients and 3 (11.1%) patients had breakthrough reactions.
Conclusion: Most of the hypersensitivity reactions to etoposide are immediate-type and not severe. Desensitization is an effective and safe procedure to manage these reactions. Further research is needed to elucidate the mechanisms of hypersensitivity reactions.

Keywords : Etoposide, hypersensitivity, desensitization, reaction, immediate, chemotherapy

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Article available in :
Volume 6, Issue 2, 2024
Page : 175-180
https://doi.org/10.38053/acmj.1430895
Article Information
Submitted : 02 Şub 2024
Accepted : 19 Şub 2024
Corresponding Author :

Gözde Köycü Buhari: Atatürk Chest Disease and Chest Surgery Training and Research Hospital, Department of Allergy and Immunology, Ankara, Turkey

[email protected]
Citation : Köycü Buhari G, Nazik Bahçecioğlu S, Gültuna S, et al. Etoposide hypersensitivity reactions and outcomes of desensitizations in immediate-type hypersensitivity reactions. Anatolian Curr Med J. 2024;6(2):175-180.

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