ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
The correlation between serum free light chain levels and plasma cell ratio in bone marrow biopsy in multiple myeloma
Abstract
Aims: MM (Multiple myeloma) is the second most common hematological malignancy. In addition to the recent advances in treatment, new parameters are used in clinical practice in diagnosis and follow-up. sFLC (free chain kappa and lambda) shows the activation of the disease depending on the rate of MM malignant cell secretion in serum. However, the plasma cell (PC) ratio in bone marrow biopsy is still the gold standard in diagnosis. We examined the dynamic correlation between the PC ratio and the number of sFLC-related cells and the secretion rate. We aimed to examine whether a low PC ratio could be in a more aggressive form with a higher sFLC secretion with too much activity, thus examining the correlation between them.
Methods: A total of 62 newly diagnosed MM patients admitted to Başkent University Faculty of Medicine İstanbul Hospital were included in the study. At the time of diagnosis, sFLC values were requested simultaneously with bone marrow biopsy. Radiological images were obtained with PET CT/MRI or CT.
Results: In all MM groups, bone marrow PH percentages were not correlated with sFLC regardless of subtype. IgG kappa type MM had the highest sFLC values despite the lowest number of PHs, while Lambda light chain MM had the lowest sFLC despite the highest PH rates.
Conclusion: These results showed us that sFLC rates are independent of the percentage of PC in MM. We believe that the two are not correlated and should be followed up together in the follow-up of the disease.

Keywords : Multiple myeloma, bone marrow biopsy, serum free light chains, radiological involvement, plasma cell ratio

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Article available in :
Volume 6, Issue 2, 2024
Page : 150-154
https://doi.org/10.38053/acmj.1429510
Article Information
Submitted : 31 Oca 2024
Accepted : 17 Şub 2024
Corresponding Author :

Alpay Yeşilaltay: Division of Hematology, Department of Internal Medicine, Başkent University İstanbul Hospital, İstanbul, Turkey

[email protected]
Citation : Yeşilaltay A, Ramadan S. The correlation between serum free light chain levels and plasma cell ratio in bone marrow biopsy in multiple myeloma. Anatolian Curr Med J. 2024;6(2):150-154.

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