ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
The relationship between increased iron load and respiratory function tests in patients diagnosed with transfusion dependent thalassemia
Abstract
Aims: Thalassaemia syndromes are the most common single gene disorders affecting more than 200 million people worldwide. Beta thalassaemia (BT) is the most common cause of transfusion-dependent thalassaemia (TDT). It has been reported in studies that iron accumulation occurs in the lungs, especially in the alveolo-capillary membrane, and the frequency of parenchymal disease increases in patients receiving frequent blood transfusions. In our study, we aimed to investigate whether there is a correlation between iron overload and pulmonary function in patients with TDT.
Methods: The study included 61 patients aged between 18 and 45 years with a diagnosis of TDT who were followed up in the hematology clinic of our tertiary care center between 2018 and 2023. Based on spirometry measurements, the pattern of respiratory impairment was defined and correlated with serum ferritin levels.
Results: The mean age of the 61 patients included in the study was 24.83±6.02 years and 33 were female and 28 were male. The mean ferritin value was 3150.88±2553.51 ng/ml. The annual number of transfusions was 15.39±1.90. According to the PFT results, mean FVC % value was 81.59±9.28, mean FEV1 % value was 82.11±7.6, mean FEV1/FVC % value was 102.55±7.63. Mean ferritin values were found to be significantly higher in patients diagnosed with TDT with restrictive lung pattern (p=0.004).
Conclusion: Our study showed that high ferritin levels are related to increased restrictive lung disease in the adult age group.

Keywords : Thalassemia, respiration, iron load

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Article available in :
Volume 6, Issue 2, 2024
Page : 139-143
https://doi.org/10.38053/acmj.1420858
Article Information
Received : 16 Oca 2024
Accepted : 11 Şub 2024
Published : 08 Mar 2024
Corresponding Author :

Cem Selim: Department of Hematology, Faculty of Medicine, Selçuk University, Konya, Turkiye

[email protected]
Citation : Selim C, Çiftçiler R. The relationship between increased iron load and respiratory function tests in patients diagnosed with transfusion dependent thalassemia. Anatolian Curr Med J. 2024;6(2):139-143.

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