ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Relationship between coronary artery disease and high-density lipoprotein cholesterol-monocyte ratio
Abstract
Aims: To investigate the association between high-density lipoprotein cholesterol (HDL-C)-to- monocyte ratio(HMR) and coronary artery disease (CAD) proven by coronary angiography.
Methods: A total of 311 patients were enrolled in the retrospective study. The grouping was based on whether the stenosis of one coronary artery exceeds 50%. Gensini Score (GS) to evaluate the severity of coronary artery stenosis. Spearman correlation analysis, progressive logistic regression, and receiver operating characteristic (ROC) curve analysis were used.
Results: The HMR difference between the CAD and non-CAD groups was statistically significant (P<0.001). Spearman correlation analysis showed that the HMR was slightly and moderately correlated with other independent risk factors of CAD (r<0.5). HMR was a new independent risk factor by progressive logistic regression analysis (odds ratio=0.784. 95% CI, 0.682-0.901). HMR was related to the GS of CAD patients (r=-0.244, P<0.001). Moreover, the HMR was better than HDL-C and HDL-C-to-cholesterol by comparing AUC (AUC HDL-C-to-monocyte=0.642, AUC HDL-C=0.603, AUC HDL-C-to-cholesterol=0.584).
Conclusion: HMR was an independent factor of CAD and can be used as a biomarker to evaluate the severity of CAD.

Keywords : Coronary artery disease, HDL-C-to-monocyte ratio, coronary angiography

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Article available in :
Volume 6, Issue 2, 2024
Page : 116-120
https://doi.org/10.38053/acmj.1409450
Article Information
Submitted : 25 Ara 2023
Accepted : 23 Oca 2024
Corresponding Author :

Eyüp Özkan: Department of Cardiology, Başakşehir Çam & Sakura City Hospital, İstanbul, Turkey

[email protected]
Citation : Özkan E, Erdoğan A. Relationship between coronary artery disease and high-density lipoprotein cholesterol-monocyte ratio. Anatolian Curr Med J. 2024;6(2):116-120.

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