ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Duodenal IgE and mast cells changes in diabetes mellitus patients
Abstract
Aims: To determine the differences in duodenal biopsies of diabetes mellitus (DM) patients and non-diabetic patients by investigating the numbers of immunoglobulin E (IgE) positive plasma cells, IgE positive mast cells, and eosinophils.
Methods: Patients diagnosed with chronic duodenitis and DM and those diagnosed only with chronic duodenitis within between 2010-2020 years were detected from the hospital information system. Paraffin blocks and hematoxylin-eosin-stained preparations of the patients’ duodenal biopsies were obtained from the hospital’s pathology archive. By performing IgE immunohistochemical staining for all blocks, the sections were evaluated through light microscopy.
Results: A total of 75 patients, 45 with DM and 30 non-diabetic patients with chronic duodenitis were included in the study. While IgE accumulation was prominently detected in the plasma cells and mast cells of DM patients’ duodenal tissue samples, no significant IgE accumulation was detected in the biopsies of non-diabetic patients with chronic duodenitis.
Conclusion: To date, the effectiveness of mast cells, IgE, and duodenal histological changes in DM have been proven, but our study is the first to detect the increase in mast cells and IgE in duodenal biopsies of DM patients. High IgE in the duodenum could support the relationship between DM and food allergy. We consider that higher IgE antibodies detected in diabetic patients’ duodenums will reveal promising novel results in elucidating DM pathophysiology and regulating the treatment modalities, and will shed light on future studies.

Keywords : Diabetes mellitus, Ig E, mast cells

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Article available in :
Volume 6, Issue 1, 2024
Page : 1-5
https://doi.org/10.38053/acmj.1342876
Article Information
Received : 14 Ağu 2023
Accepted : 10 Kas 2023
Published : 15 Oca 2024
Corresponding Author :

Ayşe Nur Uğur Kılınç: Department of Medical Pathology, Konya Training and Research Hospital, Konya, Turkiye

[email protected]
Citation : Ömeroğlu E, Uğur Kılınç AN. Duodenal IgE and mast cells changes in diabetes mellitus patients Anatolian Curr Med J. 2024;6(1):1-5.

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