ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Effects of sequential and fixed-dose estradiol valerate administration on premature progesterone rise in frozen-thawed embryo transfer cycles
Abstract
Aims: This study investigated the risk of premature progesterone (P4) rise in the fixed and sequential estradiol valerate (EV) administration for frozen embryo transfer (FET) cycles. Material and
Methods: In this cross-sectional case-control study, 1272 cycles of FET were analyzed retrospectively from computer records between January 2015 to August 2020. EV was administrated in 795 patients with a fixed dose and in 477 patients with a sequential dose. P4 values were measured on the day when the endometrial thickness reached 8 mm in the patients.
Results: There were 795 patients in the fixed EV administration group with a mean age of 30.75±3.39 and 477 patients in the sequential EV administration with a mean age of 30.75±3.39. P4 of the sequential-dose group (1.05±0.31) was significantly higher than the fixed-dose group (1.01±0.33). The Pairwise Z-Tests found that the abort rate was significantly higher in the sequential-dose group (p=0.04).
Conclusion: Our results showed a higher P4 and abortion rate in the sequential-dose group. These findings show that premature P4 rise can be considered a risk factor.

Keywords : Estradiol valerate, progesterone, FET

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Article available in :
Volume 5, Issue 1, 2023
Page : 71-75
https://doi.org/10.38053/acmj.1209514
Article Information
Submitted : 24 Kas 2022
Accepted : 28 Ara 2022
Corresponding Author :

Tuğba Gürbüz: Department of Gynecology and Obstetric Clinic, Medistate Hospital, İstanbul, Turkiye

[email protected]
Citation : Küçükakça AŞ, Ağar M, Dokuzeylül Güngör N, Gürbüz T. Effects of sequential and fixed-dose estradiol valerate administration on premature progesterone rise in frozen-thawed embryo transfer cycles. Anatolian Curr Med J 2023; 5(1); 71-75.

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