ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Original Article
Comparison of different endometrial preparation protocols in frozen-thawed embryo transfer cycles in women with polycystic ovary syndrome
Abstract
Aims: This study aimed to evaluate the most suitable endometrial preparation protocols such as hormone replacement therapy (HRT) with gonadotropin releasing hormone analogue (GnRH-a) suppression, HRT without GnRH-a suppression and mild ovarian stimulation (OS) for women with  polycystic ovary syndrome (PCOS) undergoing frozen-thawed embryo transfer (FET). Material and
Methods:  We conducted a historical cohort analysis of 161 women with PCOS who underwent the “freeze-all” strategy between December 2018 and August 2020 because of their high risk for ovarian hyperstimulation syndrome. Three endometrial preparation protocols were used: HRT with GnRH-a suppression (n=43); HRT without GnRH-a suppression (n=86); mild-OS (n=32).
Results: The biochemical pregnancy results (55.8 % vs 54.65 % vs 53, p=0.900), ongoing pregnancy rates (44.2 % vs 43 % vs 40.62, p=0.572), and abort rates (20.8 % vs 21.3 % vs 23.52, p=0.900) were similar between the HRT with GnRH-a suppression, without GnRH-a suppression and mild-OS, respectively. This study showed no statistically significant difference between the three protocols in laboratory parameters (p>0.05).
Conclusion: There was no statistically difference between three groups in terms of pregnancy outcomes. Dependent on clinical experience and facility, one of these protocols could be deployed for FET in women with PCOS.

Keywords : Frozen-thawed embryo, GnRH-a, implantation, polycystic ovary syndrome

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Article available in :
Volume 5, Issue 1, 2023
Page : 34-38
https://doi.org/10.38053/acmj.1218259
Article Information
Submitted : 13 Ara 2022
Accepted : 23 Ara 2022
Corresponding Author :

Tuğba Gürbüz: Department of Gynecology and Obstetric Clinic, Medistate Hospital, İstanbul, Turkiye

[email protected]
Citation : Önal M, Ağar M, Küçükakça AŞ, Gürbüz T. Comparison of different endometrial preparation protocols in frozen-thawed embryo transfer cycles in women with polycystic ovary syndrome. Anatolian Curr Med J 2023; 5(1); 34-38.

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