ACMJ
Anatolian Current Medical Journal

Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Araştırma Makalesi
IL-2 propagated T cells of patients with Epstein-Barr virus infection as compared to controls
Abstract
Aim: We asked whether IL-2 propagated lymphocytes from patients with Epstein-Barr virus (EBV) disease are different from IL-2 propagated cells of healthy donors and our study comes through helping about vaccine produce that use for cell therapy. Material and Method: We took blood samples from patients in policlinic or clinic. First we determined patient with EBV disease by PCR and then we phenotyped of lymphocytes by Flow cytometry. Results : All T lymphocytes expressed TCRa/b, Granzyme B, CD2, CD86 and CD3 but were not expressed CD56, CD25 and TRAIL. Especially T lymphocytes that EBV PCR positive were not expressed CD16 and CD95-L. On the other hand T lymphocytes from healthy donors expressed CD16 and CD 95-L but not expressed CD80. Conclusion: As a result of infections such as EBV , CMV , there are differences in T cell receptors.

Keywords : Epstein-Barr virus (EBV), CD marker, T cell

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Article available in :
Volume 1, Issue 2, 2019
Page : 26-32
https://doi.org/10.38053/agtd.510413
Article Information
Received : 08 Oca 2019
Accepted : 22 Mar 2019
Published : 18 Nis 2019
Corresponding Author :

Şafak Ceren: İstanbul Şişli Meslek Yüksek Okulu, İstanbul, Türkiye

[email protected]
Citation : Uçak ŞC, Torun M. Epstein-Barr virüs enfeksiyonu olan hastalardan alınan, IL-2 ile üretilen T hücrelerinin kontrollerle karşılaştırılması. Anadolu Güncel Tıp Derg 2019; 1(2): 26-32.

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