Anatolian Current Medical Journal (ACMJ) is an unbiased, peer-reviewed, and open access international medical journal. The Journal publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports, and clinical images, invited reviews, editorials, letters, comments, and related knowledge.

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Araştırma Makalesi
Relationship between adolescent varicocele and mean platelet volume
Aim: The aim of this study is to investigate the relationship between adolescent varicocele and mean platelet volume (MPV). Material and Method: Fifty nine healthy cases who applied for routine controls and 43 patients with Grade 3 varicocele aged from 11 to 19 years were included in study as Group 1 and Group 2, respectively. MPV values of both groups were statistically compared. Results: Between January 2012 and February 2018, a total of 102 cases were included in the study. The mean age of the cases was 15.12±2.12 years. The mean ages of the cases in Groups 1 and 2 were 15.07±2.18 and 15.19±2.06 years, respectively. No statistically significant difference was found between the two groups in terms of mean ages and their distribution (p> 0.05). MPV values for Groups 1 and 2 were 8.09 ± 0.69 and 9.65 ± 1.6, respectively. MPV values measured in Group 2 were significantly higher than group 1 (p<0.001). Conclusion: In our study, there was a significant relationship between adolescent varicocele and MPV . We believe that MPV elevation can be used as a guide in future studies performed on varicocele pathophysiology.

1. Richardson I, Grotas AB, Nagler HM. Outcomes of varicocelectomy treatment: an updated critical analysis. Urol Clin North Am 2008; 35: 191-209.
2. Dohle GR, Glassberg KI. How common are varicocoeles? New data on the prevalence in adolescence and new discussions. Andrology 2013; 1: 661–2.
3. Akbay E, Cayan S, Doruk E, Bozlu M. The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 2000; 86: 490-3.
4. Dubin L, Amelar RD. Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertil Steril 1970; 21: 606-60.
5. Ersöz G. Platelet Activation. Ankara Üniversitesi Tıp Fakültesi Mecmuası 1997; 3: 163-72.
6. Briggs C, Harrison P, Machin SJ. Continuing developments with the automated platelet count. Int J Lab Haematol 2007; 29: 1-15.
7. Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol 2002;118: 787-93.
8. Endler G, Klimesch A, Sunder-Plasmann H, et al. Mean platetet volume is an independent risk factor for myocardial infarction but for coronary artery disease. Br J Hmaemotal 2002;117:399-404.
9. Kisacik B, Tufan A, Kalyoncu U, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008; 75: 291-4.
10. Beyan C, Beyan E. Mean platelet volume and amyloidosis in patients with familial Mediterranean fever. Clin Rheumatol 2013; 32: 1245-6.
11. Shilpi K, Potekar RM. A Study of Platelet Indices in Type 2 Diabetes Mellitus Patients. Indian J Hematol Blood Transfus 2018; 34: 115-20.
12. Nöske HD, Weidner W. Varicocele–a historical perspective. World J Urol 1999:151-7.
13. Erdemir F, Kılıç S. Varicocele. Gaziosmanpaşa Üniv Tıp Fak Derg 2011; 3: 1-11.
14. Çayan S, Kadıoğlu A. Current approaches in the diagnosis and treatment of varicocele. Turk J Urol 2005; 31: 57-63.
15. Öztürk E, Soygür T. Adölesan varikosel (Derleme). Androloji Bül 2013; 53: 103-5.
16. Kohler FP. On the etiology of varicocele. J Urol 1967; 97: 741-2.
17. Kiliç S, Aksoy Y , Sincer I, Oğuz F, Erdil N, Yetkin E. Cardiovascular evaluation of young patients with varicocele. Fertil Steril 2007; 88: 369-73.
18. Yetkin E, Kilic S, Acikgoz N, et al. Increased prevalence of varicocele in patients with coronary artery ectasia. Coron Artery Dis 2005; 16: 261-4.
19. Koyuncu H, Ergenoglu M, Yencilek F, et al. The evaluation of saphenofemoral insufficiency in primary adult varicocele. J Androl 2011; 32: 151-4.
20. Ciaccio V , Ficola F, Ceccarelli F, Capodicasa E. [Assessment of sapheno-femoral junction continence in 42 patients with primary varicocele]. Minerva Chir 1995; 50: 469-73.
21. Özkan MTA, Seyhah S, Özdemir S. Incidence of venous ınsufficiency in patients with varicocele. Int J Clin Research 2014; 2: 156-9.
22. Ayan NN, Savaş Z, Bireroğlu N, Keleş A, Aksoy N, Serin Ö. the comparison of platelet counts between the before and after treatments of women with ıron deficiency anemia. JAREM 2015; 5: 94-6.
23. Gasparyan AY , Ayvazyan L, Mikhailidis DP, Kitas GD. Meanplatelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011; 17: 47-58.
24. Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357: 2482-94.
25. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157-61.
26. Toptaş M, Durmuş G, Akkoç İ, et al. Are mean platelet volume and platelet count associated with presence of thrombus in patients with abdominal aortic aneursym? Med Bull Haseki 2018; 56: 32-6.
27. Korkmaz L, Korkmaz AA, Akyüz AR, et al. Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: an observational study. Anadolu Kardiyol Derg 2012; 12: 35-9.
28. Sarıca MA, Kızıldağ B, Selçuk MY , et al. Mean platelet volume in patients with chronic venous insufficiency. J Clin Experimental Invest 2016; 7: 73-7.
29. Deveci Ş, Çelebi A, Aşkın S, Gürsoy AE, Kolukısa M, Hakyemez A. Relationship of mean platelet volume to an acute ischemic stroke. Ege J Med 2014; 53: 1-6.
30. Bozkurt Y , Soylemez H, Sancaktutar AA, et al. Relationship between mean platelet volume and varicocele: a preliminary study. Urology 2012; 79: 1048-51.
31. Çoban S, Keleş I, Biyik I, et al. Is there any relationship between mean platelet volume and varicocele? Andrologia 2015; 47: 37-41.
32. Çoban S, Keles I, Biyik İ, Guzelsoy M, Turkoglu AR, Ocak N. Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels? Can Urol Assoc J 2015; 9: 5-9.
33. Mahdavi-Zafarghandi R, Shakiba B, Keramati MR, Tavakkoli M. Platelet volume indices in patients with varicocele. Clin Exp Reprod Med 2014; 41: 92-5.
34. Camoglio FS, Peretti M, Bianchi F, Mariotto A, Zampieri N. Mean platelet volume and varicocele: comparison between adolescents and adults. Am J Clin Exp Urol 2015; 3: 100-6.
35. Okçelik S, Gök M, Şener İ, et al. The relationship between varicocele and mean platelet volume levels is still not clear. New J Urol 2017; 12: 17-20.
Volume 1, Issue 1, 2019
Page : 9-13